Keep as concentrated solution.
Positive Control: 293T, A431, HeLa, HepG2, HUVEC.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFalpha and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal. Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDF antibody; cholinergic differentiation factor; D factor; DIA antibody; differentiation inhibitory activity; differentiation-inducing factor; Differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA antibody; human interleukin in DA cells; Leukemia inhibitory factor; leukemia inhibitory factor antibody; LIF; Melanoma-derived LPL inhibitor; MLPLI; MLPLI antibody
Gene Aliases: CDF; DIA; HILDA; LIF; MLPLI
UniProt ID: (Human) P15018
Entrez Gene ID: (Human) 3976