The antibody detects endogenous levels of total LIF Receptor alpha protein.
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
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Protein Aliases: CD118; CD118 antigen; Leukemia inhibitory factor receptor; LIF receptor; LIF-R; SJS2; STWS; SWS
Gene Aliases: CD118; LIF-R; LIFR; SJS2; STWS; SWS
UniProt ID: (Human) P42702
Entrez Gene ID: (Human) 3977