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LILRB4 Polyclonal Antibody

View all (19) LILRB4 (CD85k) antibodies

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LILRB4 Polyclonal Antibody

Product Details

PA5-47314

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1 µg/mL
-

Flow Cytometry (Flow)

2.5 µg per million cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human LILRB4/CD85k/ILT3 Pro17-His257
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606521

Product Specific Information

In direct ELISAs and Western blots, approximately10% cross-reactivity with recombinant human (rh) ILT4 and rhILT5 is observed, and less than 5% cross-reactivity with recombinant human ILT2 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B4; CD85 antigen-like family member K; CD85k; ILT-3; Immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; Leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; LILRB4; LIR-5; Monocyte inhibitory receptor HM18; unnamed protein product

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Gene Aliases: B4; CD85K; ILT-3; ILT3; LILRB4; LIR-5; LIR5

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UniProt ID: (Human) Q8NHJ6

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Entrez Gene ID: (Human) 11006

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Function(s)
fibronectin binding protein binding protein phosphatase binding protein tyrosine kinase inhibitor activity transmembrane receptor protein tyrosine kinase inhibitor activity receptor inhibitor activity inhibitory MHC class I receptor activity apolipoprotein binding
Process(es)
adaptive immune response immune system process tolerance induction positive regulation of T cell anergy negative regulation of T cell cytokine production immune response-regulating signaling pathway Fc receptor mediated inhibitory signaling pathway cell surface receptor signaling pathway cytokine-mediated signaling pathway receptor internalization negative regulation of chemokine production negative regulation of interferon-gamma production negative regulation of interleukin-1 beta production negative regulation of interleukin-10 production negative regulation of interleukin-2 production negative regulation of interleukin-5 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of T cell proliferation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of CD8-positive, alpha-beta T cell differentiation negative regulation of MAPK cascade negative regulation of cytotoxic T cell differentiation positive regulation of regulatory T cell differentiation negative regulation of osteoclast differentiation negative regulation of activated T cell proliferation negative regulation of T cell receptor signaling pathway negative regulation of IP-10 production interleukin-10-mediated signaling pathway negative regulation of monocyte activation negative regulation of cytokine production involved in inflammatory response negative regulation of protein localization to nucleus negative regulation of intracellular signal transduction negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of T cell costimulation
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