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Invitrogen
LILRB4 Polyclonal Antibody
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Product Details
PA5-87295
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human LILRB4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B4; CD85 antigen-like family member K; CD85k; glycoprotein 49 B; ILT-3; Immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; Leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; Leukocyte immunoglobulin-like receptor subfamily B member 4A; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; LILRB4; LIR-5; Mast cell surface glycoprotein Gp49B; Monocyte inhibitory receptor HM18; unnamed protein product
Gene Aliases: B4; CD85K; gp49; Gp49b; HM18; ILT-3; ILT3; LILRB4; Lilrb4a; LIR-5; LIR5
UniProt ID: (Human) Q8NHJ6, (Mouse) Q64281
Entrez Gene ID: (Human) 11006, (Mouse) 14728
fibronectin binding
protein binding
protein phosphatase binding
protein tyrosine kinase inhibitor activity
transmembrane receptor protein tyrosine kinase inhibitor activity
receptor inhibitor activity
inhibitory MHC class I receptor activity
apolipoprotein binding
immunoglobulin receptor superfamily
adaptive immune response
immune system process
tolerance induction
positive regulation of T cell anergy
negative regulation of T cell cytokine production
immune response-regulating signaling pathway
Fc receptor mediated inhibitory signaling pathway
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
receptor internalization
negative regulation of chemokine production
negative regulation of interferon-gamma production
negative regulation of interleukin-1 beta production
negative regulation of interleukin-10 production
negative regulation of interleukin-2 production
negative regulation of interleukin-5 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of T cell proliferation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of CD8-positive, alpha-beta T cell differentiation
negative regulation of MAPK cascade
negative regulation of cytotoxic T cell differentiation
positive regulation of regulatory T cell differentiation
negative regulation of osteoclast differentiation
negative regulation of activated T cell proliferation
negative regulation of T cell receptor signaling pathway
negative regulation of IP-10 production
interleukin-10-mediated signaling pathway
negative regulation of monocyte activation
negative regulation of cytokine production involved in inflammatory response
negative regulation of protein localization to nucleus
negative regulation of intracellular signal transduction
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of T cell costimulation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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