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Invitrogen
LILRC2 Polyclonal Antibody
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Product Details
PA5-148820
Product Specifications
Species Reactivity
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant rat LILRC2, Gly24-Asn230
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
LILRC2, also known as Leukocyte Immunoglobulin-Like Receptor Subfamily C Member 2 (LILRC2), is a gene that encodes a member of the leukocyte immunoglobulin-like receptor (LILR) family. These receptors are primarily expressed on the surface of various immune cells, including B cells, dendritic cells, monocytes, and natural killer (NK) cells. LILRC2 functions as an inhibitory receptor, playing a critical role in the modulation of immune responses. By binding to specific ligands, such as major histocompatibility complex (MHC) class I molecules, LILRC2 can transmit inhibitory signals that dampen immune cell activation, thereby maintaining immune homeostasis and preventing excessive or inappropriate immune responses. This regulatory function is crucial for preventing autoimmunity and maintaining tolerance to self-antigens. Dysregulation or altered expression of LILRC2 has been associated with various immune-related conditions, including autoimmune diseases, chronic infections, and cancers. Understanding the specific roles and signaling mechanisms of LILRC2 is important for developing therapeutic strategies aimed at modulating immune responses, enhancing immune tolerance, and treating immune-mediated diseases. Research into LILRC2 provides valuable insights into the intricate balance of immune regulation and the potential for targeting inhibitory receptors in immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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