Immunogen sequence: MDKYDDLGLEA SKFIEDLNMY EASKDGLFRV DKGAGNNPEF EETRRVFATK MAKIHLQQ
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 98%.
The Zyxin family of proteins contains five members: Ajuba, Limd1, LPP, TRIP6 and Zyxin. Limd1 (LIM domain-containing protein 1) is a ubiquitously expressed tumor suppressor containing three LIM zinc-binding domains. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers. Limd1 blocks in vitro and in vivo tumor growth and is downregulated in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: LIM domain-containing protein 1
Gene Aliases: LIMD1
UniProt ID: (Human) Q9UGP4
Entrez Gene ID: (Human) 8994