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Invitrogen
LIME Polyclonal Antibody
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Product Details
PA1-19376
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with the cytoplasmic domain of LIME, a 30 kDa Lck-interacting transmembrane adaptor expressed by T cells
This antibody will not cross-react with mouse.
Target Information
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20406; Lck-interacting membrane protein; Lck-interacting molecule; Lck-interacting transmembrane adapter 1; lime 1; RP4-583P15.5; unnamed protein product
Gene Aliases: dJ583P15.4; LIME; LIME1; LP8067
UniProt ID: (Human) Q9H400
Entrez Gene ID: (Human) 54923
adaptive immune response
immune system process
regulation of transcription from RNA polymerase II promoter
regulation of I-kappaB kinase/NF-kappaB signaling
T cell receptor signaling pathway
B cell receptor signaling pathway
regulation of release of sequestered calcium ion into cytosol
regulation of protein kinase B signaling
regulation of NIK/NF-kappaB signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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