Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MANALASAT CERCKGGFAP AEKIVNSNGE LYHEQCFVCA QCFQQFPEGL FYEFEGRKYC EHDFQMLFAP CCHQCGEFTI GRVIKAMNNS WHPECFRCDL CQEVLADIGF VKNAGRHLCR PCHNREKARG LGKYICQKCH AIIDEQPLIF KNDPYHPDHF NCANCGKELT ADARELKGEL YCLPCHDKMG VPICGACRRP IEGRVVNAMG KQWHVEHFVC AKCEKPFLGH RHYERKGLAY CETHYNQLFG DVCFHCNRVI EGGVVSALNK AWCVNCFACS TCNTKLTLKN KFVEFDMKPV CKKCYEKFPL ELKKRLKKLA ETLGRK (1-325 aa encoded by B C005341)
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
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