A suggested positive control is Raji cell lysate.
PA5-20898 can be used with blocking peptide PEP-1012.
Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A; Lin-28A; Protein lin-28 homolog A; RNA-binding protein LIN-28; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
Gene Aliases: CSDD1; LIN-28; lin-28A; LIN28; LIN28A; ZCCHC1
UniProt ID: (Human) Q9H9Z2
Entrez Gene ID: (Human) 79727
Molecular Function: DNA binding protein