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Proteintech
LIN41 Polyclonal Antibody
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Product Details
55003-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to TRIM71.
Target Information
TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: abnormal cell LINeage LIN-41; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41); Drosophila dappled/ vertebrate TRipartite Motif protein related; E3 ubiquitin-protein ligase TRIM71; homolog of C. elegans Lin-41; lin-41 homolog; mLin41; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing 71; Tripartite motif-containing protein 71
Gene Aliases: 2610206G21Rik; AL022943; Gm1127; LIN-41; LIN41; mlin-41; mLin41; RGD1566388; TRIM71
UniProt ID: (Human) Q2Q1W2, (Mouse) Q1PSW8, (Rat) D3ZVM4
Entrez Gene ID: (Human) 131405, (Mouse) 636931, (Rat) 301042
ubiquitin-protein transferase activity
zinc ion binding
ligase activity
translation repressor activity
miRNA binding
ubiquitin protein ligase activity
RNA binding
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
G1/S transition of mitotic cell cycle
neural tube closure
fibroblast growth factor receptor signaling pathway
miRNA metabolic process
negative regulation of translation
neural tube development
miRNA mediated inhibition of translation
protein autoubiquitination
regulation of gene silencing by miRNA
3'-UTR-mediated mRNA destabilization
stem cell proliferation
regulation of neural precursor cell proliferation
positive regulation of gene silencing by miRNA
multicellular organism development
gene silencing by RNA
regulation of protein metabolic process
cellular response to organic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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