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Invitrogen
LIPC Polyclonal Antibody
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Product Details
PA5-36962
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the 349-394 of human LIPC
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 56 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The Lipase family belongs to one of the most robust genetic superfamilies found in living organisms that includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Balancing the composition and the transport of lipoproteins in human plasma is essential for normal body function and is mediated in part by Hepatic Lipase, also known as HL or LIPC. Rare deficiencies in Hepatic Lipase have been identified in humans which lead to pathologic levels of circulating lipoprotein particles; this condition is associated with coronary artery disease (CAD). Hepatic Lipase is regulated by thyroid hormones and has a dual function as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake. Hepatic Lipase localizes to the endothelial surfaces of extrahepatic tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hepatic lipase; hepatic lipase precursor; Hepatic triacylglycerol lipase; HL; lipase C; Lipase member C; lipase, hepatic; Lysophospholipase; Phospholipase A1; Triacylglycerol lipase; triglyceride lipase precursor; unnamed protein product
Gene Aliases: AI256194; HDLCQ12; HL; Hpl; HTGL; LIPC; LIPH
UniProt ID: (Human) P11150, (Mouse) P27656
Entrez Gene ID: (Human) 3990, (Rat) 24538, (Mouse) 15450
lipoprotein lipase activity
phospholipase activity
lysophospholipase activity
triglyceride lipase activity
protein binding
heparin binding
phosphatidylcholine 1-acylhydrolase activity
lipase activity
hydrolase activity
low-density lipoprotein particle binding
apolipoprotein binding
carboxylic ester hydrolase activity
lipid binding
transferase activity, transferring acyl groups
chylomicron binding
heparan sulfate proteoglycan binding
acylglycerol lipase activity
lipase
lipid metabolic process
fatty acid biosynthetic process
cholesterol metabolic process
lipid catabolic process
triglyceride catabolic process
cholesterol transport
very-low-density lipoprotein particle remodeling
intermediate-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
chylomicron remnant clearance
phosphatidylcholine catabolic process
cholesterol homeostasis
reverse cholesterol transport
triglyceride homeostasis
response to hypoxia
liver development
fatty acid metabolic process
triglyceride metabolic process
phosphatidylserine metabolic process
circadian rhythm
response to hormone
response to carbohydrate
response to acetate
response to inorganic substance
response to organic cyclic compound
heparan sulfate proteoglycan biosynthetic process
response to nutrient levels
response to magnesium ion
cellular response to hormone stimulus
response to lipid
chylomicron remodeling
low-density lipoprotein particle clearance
response to drug
response to amino acid
response to peptide hormone
phosphatidylethanolamine metabolic process
neutral lipid catabolic process
phosphatidylcholine metabolic process
phosphatidic acid metabolic process
glycerophospholipid catabolic process
response to copper ion
developmental growth
protein oligomerization
response to glucocorticoid
response to calcium ion
response to fatty acid
regulation of plasma lipoprotein particle levels
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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