NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.
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Protein Aliases: endothelial lipase; gastric lipase; Gastric triacylglycerol lipase; GL; lipase, gastric; LIPE; MGC138477; MGC142271
Gene Aliases: GL; HGL; HLAL; LIPF
UniProt ID: (Human) P07098
Entrez Gene ID: (Human) 8513