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Invitrogen
LIS1 Polyclonal Antibody
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Product Details
PA5-18048
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (TGSVDQTVKVWECR) corresponding to the C-terminus amino acids of PAFAH1B1 (aa 397-410).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse and porcine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIS-1; LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141}; lissencephaly 1 protein; Lissencephaly-1 protein; lissencephaly-1 protein {ECO:0000255|HAMAP-Rule:MF_03141}; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF acetylhydrolase 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH 45 kDa subunit; PAF-AH 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH alpha; PAF-AH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH beta; PAFAH alpha; PAFAH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PAFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta); Platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase IB subunit alpha {ECO:0000255|HAMAP-Rule:MF_03141}; Platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD); platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa; platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa); RP23-194P5.2
Gene Aliases: Lis-1; LIS1; LIS2; MDCR; MDS; NudF; PAFAH; PAFAH1B1; PAFAHA
UniProt ID: (Human) P43034, (Rat) P63004
Entrez Gene ID: (Human) 5048, (Rat) 83572
phospholipase A2 activity
protein binding
microtubule binding
heparin binding
protein complex binding
dynactin binding
protein homodimerization activity
phospholipase binding
dynein binding
dynein intermediate chain binding
phosphoprotein binding
platelet-activating factor acetyltransferase activity
establishment of mitotic spindle orientation
microtubule cytoskeleton organization
ameboidal-type cell migration
acrosome assembly
neuron migration
positive regulation of cytokine-mediated signaling pathway
microtubule-based process
mitotic nuclear division
nuclear migration
chemical synaptic transmission
neuroblast proliferation
brain development
learning or memory
retrograde axonal transport
adult locomotory behavior
protein secretion
negative regulation of neuron projection development
lipid catabolic process
cell migration
stem cell division
transmission of nerve impulse
corpus callosum morphogenesis
hippocampus development
layer formation in cerebral cortex
cerebral cortex neuron differentiation
cerebral cortex development
actin cytoskeleton organization
microtubule organizing center organization
osteoclast development
positive regulation of axon extension
positive regulation of mitotic cell cycle
negative regulation of JNK cascade
vesicle transport along microtubule
brain morphogenesis
neuromuscular process controlling balance
nuclear envelope disassembly
establishment of centrosome localization
G2/M transition of mitotic cell cycle
sister chromatid cohesion
germ cell development
positive regulation of embryonic development
establishment of planar polarity of embryonic epithelium
regulation of GTPase activity
cortical microtubule organization
platelet activating factor metabolic process
auditory receptor cell development
positive regulation of dendritic spine morphogenesis
regulation of microtubule cytoskeleton organization
cochlea development
microtubule cytoskeleton organization involved in establishment of planar polarity
regulation of microtubule motor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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