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Invitrogen
LKB1 Polyclonal Antibody
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Product Details
PA1-12767
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human LKB1/STK11 serine/threonine kinase.
Conjugate
Form
Liquid
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for this product is lung or uterus lysate.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAMK group; CAMKL family; Liver kinase B1; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11
Gene Aliases: hLKB1; LKB1; PJS; STK11
UniProt ID: (Human) Q15831
Entrez Gene ID: (Human) 6794
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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