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LL-37 Polyclonal Antibody
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FIGURE: 1 / 1
LL-37 Antibody (OSC00028G-500UG) in ICC/IF
Staining of a cytospin preparation of peripheral blood mononuclear cells isolated from buffycoat. Cells were left to air dry and then fixed with cold acetone (90 seconds) and blocked with PBS containing 1% FCS and 0.1% saponin (blocking buffer) for 20 minutes. Cells were then washed twice in PBS and incubated with Rabbit antibody to LL-37 (OSC00028G), diluted 50 µg/mL: in blocking buffer, for 1 hour at room temperature. Cells were washed twice in PBS followed by incubation for 30 minutes with the FITC-labeled secondary antibody. Finally, c... View More
Product Details
OSC00028G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from human Cathelicidin antimicrobial peptide conjugated to an immunogenic carrier protein has been used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Amount
500 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Cathelicidin antimicrobial peptide.
Target Information
LL-37 is a cationic antimicrobial peptide derived from the precursor protein hCAP18, which is encoded by the CAMP gene. It is produced by epithelial cells and immune cells such as neutrophils and plays an important role in innate immunity. LL-37 exhibits broad antimicrobial activity against bacteria, viruses, and fungi, and also functions as an immunomodulatory molecule by influencing inflammation, chemotaxis, and wound healing. In addition to host defense, dysregulated LL-37 expression has been associated with inflammatory diseases and certain cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAMP; CAP-18; Cathelicidin antimicrobial peptide; epididymis secretory sperm binding protein
Gene Aliases: CAMP; CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37
UniProt ID: (Human) P49913
Entrez Gene ID: (Human) 820
response to yeast
innate immune response in mucosa
immune system process
prostaglandin production involved in inflammatory response
chronic inflammatory response
positive regulation of antimicrobial humoral response
defense response
positive regulation of cell proliferation
response to glucose
leukotriene biosynthetic process
antibacterial humoral response
antifungal humoral response
cytolysis
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of insulin secretion involved in cellular response to glucose stimulus
modification of morphology or physiology of other organism
neutrophil activation
defense response to bacterium
negative regulation of apoptotic process
innate immune response
positive regulation of angiogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
cytolysis by host of symbiont cells
killing by host of symbiont cells
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to exogenous dsRNA
positive regulation of monocyte chemotactic protein-1 production
positive regulation of macrophage inflammatory protein 1 alpha production
dentinogenesis
cellular response to butyrate
amyloid fibril formation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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