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Proteintech
LMAN1 Polyclonal Antibody
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Product Details
13364-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ERGIC-53 Fusion Protein Ag4183 (35-401 aa encoded by BC032330)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GDPAVALPH RRFEYKYSFK GPHLVQSDGT VPFWAHAGNA IPSSDQIRVA PSLKSQRGSV WTKTKAAFEN WEVEVTFRVT GRGRIGADGL AIWYAENQGL EGPVFGSADL WNGVGIFFDS FDNDGKKNNP AIVIIGNNGQ IHYDHQNDGA SQALASCQRD FRNKPYPVRA KITYYQNTLT VMINNGFTPD KNDYEFCAKV ENMIIPAQGH FGISAATGGL ADDHDVLSFL TFQLTEPGKE PPTPDKEISE KEKEKYQEEF EHFQQELDKK KEEFQKGHPD LQGQPAEEIF ESVGDRELRQ VFEGQNRIHL EIKQLNRQLD MILDEQRRYV SSLTEEISKR GAGMPGQHGQ ITQQELDTVV KTQHEILR (35-401 aa encoded by BC032330 )
Target Information
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: endoplasmic reticulum-golgi intermediate compartment protein 53; ER-Golgi intermediate compartment 53 kDa protein; Gp58; Intracellular mannose-specific lectin MR60; Lectin mannose-binding 1; lectin, mannose-binding, 1; p58; Protein ERGIC-53
Gene Aliases: 2610020P13Rik; AI326273; AU043785; C730041J05; ERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; LMAN1; MCFD1; MR60; P58
UniProt ID: (Human) P49257, (Mouse) Q9D0F3, (Rat) Q62902
Entrez Gene ID: (Human) 3998, (Mouse) 70361, (Rat) 116666
protein folding
ER to Golgi vesicle-mediated transport
endoplasmic reticulum organization
Golgi organization
blood coagulation
positive regulation of organelle organization
protein N-linked glycosylation via asparagine
protein exit from endoplasmic reticulum
early endosome to Golgi transport
COPII vesicle coating
transport
protein transport
vesicle-mediated transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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