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LMAN1 Polyclonal Antibody

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Antibody Testing Data (11)

LMAN1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

LMAN1 Antibody (13364-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed A549 cells using 13364-1-AP (ERGIC-53 antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

LMAN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LMAN1 Antibody in Immunoprecipitation (IP)

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Product Details

13364-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 11 publications 11 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ERGIC-53 Fusion Protein Ag4183 (35-401 aa encoded by BC032330)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GDPAVALPH RRFEYKYSFK GPHLVQSDGT VPFWAHAGNA IPSSDQIRVA PSLKSQRGSV WTKTKAAFEN WEVEVTFRVT GRGRIGADGL AIWYAENQGL EGPVFGSADL WNGVGIFFDS FDNDGKKNNP AIVIIGNNGQ IHYDHQNDGA SQALASCQRD FRNKPYPVRA KITYYQNTLT VMINNGFTPD KNDYEFCAKV ENMIIPAQGH FGISAATGGL ADDHDVLSFL TFQLTEPGKE PPTPDKEISE KEKEKYQEEF EHFQQELDKK KEEFQKGHPD LQGQPAEEIF ESVGDRELRQ VFEGQNRIHL EIKQLNRQLD MILDEQRRYV SSLTEEISKR GAGMPGQHGQ ITQQELDTVV KTQHEILR (35-401 aa encoded by BC032330 )

Target Information

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Development of VHL-recruiting STING PROTACs that suppress innate immunity.

Cellular and molecular life sciences : CMLS

Zhu Z,Johnson RL,Zhang Z,Herring LE,Jiang G,Damania B,James LI,Liu P

Sun May 14 00:00:00 EDT 2023

Immunofluorescence Microscopy of the Mammalian Golgi Apparatus.

Methods in molecular biology (Clifton, N.J.)

Arab M,Nayak SC,Vitali T,Lowe M

Thu Dec 15 00:00:00 EST 2022

Immunofluorescence Microscopy of the Mammalian Golgi Apparatus.

Methods in molecular biology (Clifton, N.J.)

Arab M,Nayak SC,Vitali T,Lowe M

Thu Dec 15 00:00:00 EST 2022

The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1).

Retrovirology

Henke W,Waisner H,Arachchige SP,Kalamvoki M,Stephens E

Sat Nov 19 00:00:00 EST 2022

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.

Autophagy

Yan JM,Zhang WK,Yan LN,Jiao YJ,Zhou CM,Yu XJ

Fri Jul 01 00:00:00 EDT 2022

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.

Autophagy

Yan JM,Zhang WK,Yan LN,Jiao YJ,Zhou CM,Yu XJ

Fri Jul 01 00:00:00 EDT 2022

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.

Autophagy

Yan JM,Zhang WK,Yan LN,Jiao YJ,Zhou CM,Yu XJ

Fri Jul 01 00:00:00 EDT 2022

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.

Autophagy

Yan JM,Zhang WK,Yan LN,Jiao YJ,Zhou CM,Yu XJ

Fri Jul 01 00:00:00 EDT 2022

STING1 is essential for an RNA-virus triggered autophagy.

Autophagy

Zhang R,Qin X,Yang Y,Zhu X,Zhao S,Zhang Z,Su Q,Zhao Z,Yin X,Meng X,Zhang Z,Li Y

Fri Apr 01 00:00:00 EDT 2022

The Envelope Proteins from SARS-CoV-2 and SARS-CoV Potently Reduce the Infectivity of Human Immunodeficiency Virus type 1 (HIV-1).

Research square

Henke W,Waisner H,Arachchige SP,Kalamvoki M,Stephens E

Mon Oct 24 00:00:00 EDT 2022

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.

Traffic (Copenhagen, Denmark)

Lu CL,Ortmeier S,Brudvig J,Moretti T,Cain J,Boyadjiev SA,Weimer JM,Kim J

Sat Jan 01 00:00:00 EST 2022

SARS-CoV-2 triggers Golgi fragmentation via down-regulation of GRASP55 to facilitate viral trafficking.

bioRxiv : the preprint server for biology

Zhang J,Kennedy A,Xing L,Bui S,Reid W,Joppich J,Ahat E,Rose M,Tang Q,Tai AW,Wang Y

Wed Mar 09 00:00:00 EST 2022

BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.

EMBO molecular medicine

Donkervoort S,Krause N,Dergai M,Yun P,Koliwer J,Gorokhova S,Geist Hauserman J,Cummings BB,Hu Y,Smith R,Uapinyoying P,Ganesh VS,Ghosh PS,Monaghan KG,Edassery SL,Ferle PE,Silverstein S,Chao KR,Snyder M,Ellingwood S,Bharucha-Goebel D,Iannaccone ST,Dal Peraro M,Foley AR,Savas JN,Bolduc V,Fasshauer D,Bönnemann CG,Schwake M

Tue Dec 07 00:00:00 EST 2021

BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.

EMBO molecular medicine

Tue Dec 07 00:00:00 EST 2021

Subcellular localization of nucleocapsid protein of SFTSV and its assembly into the ribonucleoprotein complex with L protein and viral RNA.

Scientific reports

Lokupathirage SMW,Tsuda Y,Ikegame K,Noda K,Muthusinghe DS,Kozawa F,Manzoor R,Shimizu K,Yoshimatsu K

Fri Nov 26 00:00:00 EST 2021

Homeostatic regulation of STING by retrograde membrane traffic to the ER.

Nature communications

Mukai K,Ogawa E,Uematsu R,Kuchitsu Y,Kiku F,Uemura T,Waguri S,Suzuki T,Dohmae N,Arai H,Shum AK,Taguchi T

Mon Jan 04 00:00:00 EST 2021

Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.

Cell metabolism

Wang X,Wang H,Xu B,Huang D,Nie C,Pu L,Zajac GJM,Yan H,Zhao J,Shi F,Emmer BT,Lu J,Wang R,Dong X,Dai J,Zhou W,Wang C,Gao G,Wang Y,Willer C,Lu X,Zhu Y,Chen XW

Tue Feb 02 00:00:00 EST 2021

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.

Cell metabolism

Huang D,Xu B,Liu L,Wu L,Zhu Y,Ghanbarpour A,Wang Y,Chen FJ,Lyu J,Hu Y,Kang Y,Zhou W,Wang X,Ding W,Li X,Jiang Z,Chen J,Zhang X,Zhou H,Li JZ,Guo C,Zheng W,Zhang X,Li P,Melia T,Reinisch K,Chen XW

Tue Aug 03 00:00:00 EDT 2021

Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor.

Nature communications

Yagi H,Yagi-Utsumi M,Honda R,Ohta Y,Saito T,Nishio M,Ninagawa S,Suzuki K,Anzai T,Kamiya Y,Aoki K,Nakanishi M,Satoh T,Kato K

Fri Mar 13 00:00:00 EDT 2020

Blood coagulation factor VIII D1241E polymorphism leads to a weak malectin interaction and reduction of factor VIII posttranslational modification and secretion.

Experimental cell research

Jiang N,Xiao Y,Liu Y,Liu W,Liu S

Tue Dec 01 00:00:00 EST 2020

Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer.

Experimental cell research

Fukamachi M,Kasamatsu A,Endo-Sakamoto Y,Fushimi K,Kasama H,Iyoda M,Minakawa Y,Shiiba M,Tanzawa H,Uzawa K

Sun Jul 01 00:00:00 EDT 2018

Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer.

Experimental cell research

Fukamachi M,Kasamatsu A,Endo-Sakamoto Y,Fushimi K,Kasama H,Iyoda M,Minakawa Y,Shiiba M,Tanzawa H,Uzawa K

Sun Jul 01 00:00:00 EDT 2018

Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer.

Experimental cell research

Fukamachi M,Kasamatsu A,Endo-Sakamoto Y,Fushimi K,Kasama H,Iyoda M,Minakawa Y,Shiiba M,Tanzawa H,Uzawa K

Sun Jul 01 00:00:00 EDT 2018

Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer.

Experimental cell research

Fukamachi M,Kasamatsu A,Endo-Sakamoto Y,Fushimi K,Kasama H,Iyoda M,Minakawa Y,Shiiba M,Tanzawa H,Uzawa K

Sun Jul 01 00:00:00 EDT 2018

An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia.

Leukemia

Angenendt L,Reuter S,Kentrup D,Benk AS,Neumann F,Hüve J,Martens AC,Schwöppe C,Kessler T,Schmidt LH,Sauer T,Brand C,Mikesch JH,Lenz G,Mesters RM,Müller-Tidow C,Hartmann W,Wardelmann E,Neri D,Berdel WE,Roesli C,Schliemann C

Thu Feb 01 00:00:00 EST 2018

Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice.

The Journal of biological chemistry

Li X,Liu L,Li R,Wu A,Lu J,Wu Q,Jia J,Zhao M,Song H

Fri Apr 06 00:00:00 EDT 2018

Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice.

The Journal of biological chemistry

Li X,Liu L,Li R,Wu A,Lu J,Wu Q,Jia J,Zhao M,Song H

Fri Apr 06 00:00:00 EDT 2018

Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.

Frontiers in cellular and infection microbiology

Luo T,Dunphy PS,McBride JW

Thu Jan 11 00:00:00 EST 2018

Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.

Frontiers in cellular and infection microbiology

Luo T,Dunphy PS,McBride JW

Thu Jan 11 00:00:00 EST 2018

Bioinformatics

Protein Aliases: endoplasmic reticulum-golgi intermediate compartment protein 53; ER-Golgi intermediate compartment 53 kDa protein; Gp58; Intracellular mannose-specific lectin MR60; Lectin mannose-binding 1; lectin, mannose-binding, 1; p58; Protein ERGIC-53

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Gene Aliases: 2610020P13Rik; AI326273; AU043785; C730041J05; ERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; LMAN1; MCFD1; MR60; P58

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UniProt ID: (Human) P49257, (Mouse) Q9D0F3, (Rat) Q62902

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Entrez Gene ID: (Human) 3998, (Mouse) 70361, (Rat) 116666

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Function(s)

protein binding mannose binding metal ion binding unfolded protein binding carbohydrate binding identical protein binding calcium ion binding membrane traffic protein

Process(es)

protein folding ER to Golgi vesicle-mediated transport endoplasmic reticulum organization Golgi organization blood coagulation positive regulation of organelle organization protein N-linked glycosylation via asparagine protein exit from endoplasmic reticulum early endosome to Golgi transport COPII vesicle coating transport protein transport vesicle-mediated transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LMAN1 Polyclonal Antibody

LMAN1 Antibody (13364-1-AP) in ICC/IF

Product Details

13364-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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