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Invitrogen
LMAN1 Polyclonal Antibody
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Product Details
PA5-87900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 270-480 of human LMAN1 (NP_0055611)
Conjugate
Form
Liquid
Concentration
3.02 mg/mL
Amount
302 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PGKEPPTPDK EISEKEKEKY QEEFEHFQQE LDKKKEEFQK GHPDLQGQPA EEIFESVGDR ELRQVFEGQN RIHLEIKQLN RQLDMILDEQ RRYVSSLTEE ISKRGAGMPG QHGQITQQEL DTVVKTQHEI LRQVNEMKNS MSETVRLVSG MQHPGSAGGV YETTQHFIDI KEHLHIVKRD IDNLVQRNMP SNEKPKCPEL PPFPSCLSTV H; Positive Samples: BT-474, LO2, U-251MG; Cellular Location: Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Single-pass membrane protein, Single-pass type I membrane protein
Target Information
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endoplasmic reticulum-golgi intermediate compartment protein 53; ER-Golgi intermediate compartment 53 kDa protein; ERGIC53; Gp58; Intracellular mannose-specific lectin MR60; Lectin mannose-binding 1; p58; Protein ERGIC-53; unnamed protein product
Gene Aliases: 2610020P13Rik; AI326273; AU043785; C730041J05; ERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; LMAN1; MCFD1; MR60; P58
UniProt ID: (Human) P49257, (Mouse) Q9D0F3, (Rat) Q62902
Entrez Gene ID: (Human) 3998, (Mouse) 70361, (Rat) 116666
in utero embryonic development
protein folding
ER to Golgi vesicle-mediated transport
endoplasmic reticulum organization
Golgi organization
blood coagulation
gene expression
positive regulation of organelle organization
protein transport
vesicle-mediated transport
protein exit from endoplasmic reticulum
early endosome to Golgi transport
negative regulation of protein targeting to mitochondrion
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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