Positive Control: Daudi cell lysates, EA.hy926, RAW264.7, SW620, rat womb tissue, human tonsil tissue, human bone marrow tissue, human womb tissue, mouse brain tissue.
Subcellular Location: Nucleus.
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: Cysteine-rich protein TTG-2; LIM domain only 2 (rhombotin-like 1); LIM domain only protein 2; LIM only 2; LMO-2; rhombotin 2; Rhombotin-2; rhombotin-like 1; T-cell translocation gene 2; T-cell translocation protein 2
Gene Aliases: LMO2; Rbtn-2; RBTN2; RBTNL1; Rhom-2; RHOM2; TTG2