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Invitrogen
LMTK2 Polyclonal Antibody
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Product Details
PA5-106513
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LMTK2(Accession Q8IWU2), corresponding to amino acid residues K665-N715.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total LMTK2.
Target Information
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; CDK5/p35-regulated kinase; CPRK; cyclin-dependent kinase 5/p35-regulated kinase; FLJ46659; hBREK; kinase phosphatase inhibitor 2; Kinase/phosphatase/inhibitor 2; KPI-2 protein; Lemur tyrosine kinase 2; LMKT2; protein phosphatase 1, regulatory subunit 100; Serine/threonine-protein kinase KPI-2; Serine/threonine-protein kinase LMTK2
Gene Aliases: 2900041G10Rik; A330101P12Rik; AATYK2; BREK; cprk; hBREK; KIAA1079; KPI-2; KPI2; LMR2; LMTK2; PPP1R100
UniProt ID: (Human) Q8IWU2, (Mouse) Q3TYD6
Entrez Gene ID: (Human) 22853, (Mouse) 231876
protein serine/threonine kinase activity
protein phosphatase inhibitor activity
protein binding
ATP binding
myosin VI binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
receptor recycling
protein phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
endocytic recycling
transferrin transport
negative regulation of catalytic activity
early endosome to late endosome transport
protein autophosphorylation
nervous system development
axon guidance
phosphorylation
neurotrophin TRK receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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