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Invitrogen
LMX1A Polyclonal Antibody
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Product Details
PA5-34470
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide near the carboxy terminus of human LMX1A
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-34470 can be used with blocking peptide PEP-1512.
Target Information
The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX-1; LMX-1.1; MGC87616; shaker short-tail; unnamed protein product
Gene Aliases: DFNA7; dr; dreher; LMX1; LMX1.1; LMX1A; sst
UniProt ID: (Human) Q8TE12, (Mouse) Q9JKU8
Entrez Gene ID: (Human) 4009, (Rat) 289201, (Mouse) 110648
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
metal ion binding
sequence-specific double-stranded DNA binding
molecular_function
zinc ion binding
sequence-specific DNA binding
regulation of cell growth
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
axon guidance
central nervous system development
memory
locomotory behavior
regulation of gene expression
dentate gyrus development
cerebellum development
hippocampus development
central nervous system neuron differentiation
neuron differentiation
midbrain development
olfactory behavior
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
synapse organization
dopaminergic neuron differentiation
midbrain dopaminergic neuron differentiation
brain development
transcription, DNA-templated
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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