Search
Proteintech
LMX1B Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
18278-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LMX1B Fusion Protein Ag13096 (1-372 aa encoded by BC112120)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLDGIKMEE HALRPGPATL GVLLGSDCPH PAVCEGCQRP ISDRFLMRVN ESSWHEECLQ CAACQQALTT SCYFRDRKLY CKQDYQQLFA AKCSGCMEKI APTEFVMRAL ECVYHLGCFC CCVCERQLRK GDEFVLKEGQ LLCKGDYEKE KDLLSSVSPD ESDSVKSEDE DGDMKPAKGQ GSQSKGSGDD GKDPRRPKRP RTILTTQQRR AFKASFEVSS KPCRKVRETL AAETGLSVRV VQVWFQNQRA KMKKLARRHQ QQQEQQNSQR LGQEVLSSRM EGMMASYTPL APPQQQIVAM EQSPYGSSDP FQQGLTPPQM PGNDSIFHDI DSDTSLTSLS DCFLGSSDVG SLQARVGNPI DRLYSMQSSY FAS (1-372 aa encoded by BC112120)
Target Information
LMX1B, LIM homeobox transcription factor 1B, belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: LIM homeo box transcription factor 1B; LIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX-1.2
Gene Aliases: FSGS10; LMX1.1; LMX1.2; LMX1B; NPS1
UniProt ID: (Human) O60663, (Mouse) O88609
Entrez Gene ID: (Human) 4010, (Rat) 114501, (Mouse) 16917
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
molecular_function
zinc ion binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
dorsal/ventral pattern formation
neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
dopaminergic neuron differentiation
neuron migration
trabecular meshwork development
biological_process
cell proliferation
regulation of gene expression
cerebellum morphogenesis
central nervous system neuron development
collagen fibril organization
midbrain development
limb morphogenesis
organ growth
camera-type eye development
transcription, DNA-templated
multicellular organism development
embryonic limb morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support