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Invitrogen
LONP1 Polyclonal Antibody
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Product Details
PA5-51692
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LONP1. Recombinant protein control fragment (Product #RP-99402).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VEEKIKQTHR KYLLQEQLKI IKKELGLEKD DKDAIEEKFR ERLKELVVPK HVMDVVDEEL SKLGLLDNHS SEFNVTRNYL DWLTSIPWGK YSNENLDLAR AQAVLEEDHY GMEDVKKRIL EFIAVSQLRG STQGKILCFY GP
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}; Lon protease-like protein; lon protease-like protein {ECO:0000255|HAMAP-Rule:MF_03120}; LONHs; LONP; LONP {ECO:0000255|HAMAP-Rule:MF_03120}; Mitochondrial ATP-dependent protease Lon; mitochondrial ATP-dependent protease Lon {ECO:0000255|HAMAP-Rule:MF_03120}; mitochondrial lon protease-like protein; protease, serine, 15; Serine protease 15; serine protease 15 {ECO:0000255|HAMAP-Rule:MF_03120}; unnamed protein product
Gene Aliases: 1200017E13Rik; CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15
UniProt ID: (Human) P36776, (Mouse) Q8CGK3, (Rat) Q924S5
Entrez Gene ID: (Human) 9361, (Mouse) 74142, (Rat) 170916
nucleotide binding
mitochondrial RNA polymerase regulatory region DNA binding
DNA binding
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
protein binding
ATP binding
peptidase activity
serine-type peptidase activity
hydrolase activity
ATPase activity
PH domain binding
identical protein binding
ADP binding
insulin receptor substrate binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
mitochondrial light strand promoter anti-sense binding
mitochondrial heavy strand promoter anti-sense binding
mitochondrial light strand promoter sense binding
mitochondrial heavy strand promoter sense binding
serine protease
mitochondrial genome maintenance
response to hypoxia
proteolysis
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
response to hormone
response to aluminum ion
protein catabolic process
mitochondrial DNA metabolic process
cellular response to oxidative stress
mitochondrial protein catabolic process
negative regulation of insulin receptor signaling pathway
chaperone-mediated protein complex assembly
proteolysis involved in cellular protein catabolic process
protein-containing complex assembly
oxidation-dependent protein catabolic process
cellular protein complex assembly
protein homooligomerization
aging
regulation of mitochondrial DNA replication
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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