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Proteintech
LOXL2 Polyclonal Antibody
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Product Details
15232-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LOXL2 fusion protein Ag7083
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Amount
67.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AMGLQKKLRL NGGRNPYEGR VEVLVERNGS LVWGMVCGQN WGIVEAMVVC RQLGLGFASN AFQETWYWHG DVNSNKVVMS GVKCSGTELS LAHCRHDGED VACPQGGVQY GAGVACSETA PDLVLNAEMV QQTTYLEDRP MFLLQCAMEE NCLSASAAQT DPTTGYRRLL RFSSQIHNNG QSDFRPKNGR HAWIWHDCHR HYHSMEVFTH YDLLNLNGTK VAEGHKASFC LEDTECEGDI QKNYECANFG DQGITMGCWD MYRHDIDCQW VDITDVPPGD YLFQVVINPN FEVAESDYSN NIMKCRSRYD GHRIWMYNCH IGGSFSEETE KKFEHFSGLL NNQLSPQ
Target Information
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: LOXL2 DELTA e13; Lysyl oxidase homolog 2; lysyl oxidase related 2; lysyl oxidase-like 2 delta e13; lysyl oxidase-like 2 protein; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14; unnamed protein product
Gene Aliases: LOR; LOR2; LOXL2; WS9-14
UniProt ID: (Human) Q9Y4K0
Entrez Gene ID: (Human) 4017
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
epithelial to mesenchymal transition
endothelial cell proliferation
sprouting angiogenesis
chromatin organization
positive regulation of epithelial to mesenchymal transition
peptidyl-lysine oxidation
collagen fibril organization
positive regulation of chondrocyte differentiation
protein modification process
endothelial cell migration
negative regulation of transcription, DNA-templated
response to copper ion
heterochromatin organization
negative regulation of stem cell population maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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