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Invitrogen
LOXL2 Polyclonal Antibody
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Product Details
PA5-32899
Product Specifications
Species Reactivity
Bat,
Bovine,
Dog,
Horse,
Human,
Non-human primate,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 15 amino acid peptide from N-terminus of human LOXL2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset, Dog, Bovine, Bat, Elephant, Panda, Horse, Rabbit (100%).
Target Information
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lysyl oxidase homolog 2; lysyl oxidase related 2; lysyl oxidase-like 2 delta e13; lysyl oxidase-like 2 protein; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14
Gene Aliases: LOR2; LOXL2; WS9-14
UniProt ID: (Human) Q9Y4K0, (Bovine) A6H737
Entrez Gene ID: (Rabbit) 100346678, (Horse) 100058083, (Human) 4017, (Bovine) 532684, (Dog) 486118
response to hypoxia
epithelial to mesenchymal transition
endothelial cell proliferation
sprouting angiogenesis
transcription, DNA-templated
cellular protein modification process
receptor-mediated endocytosis
cell adhesion
aging
histone modification
protein deamination
collagen fibril organization
positive regulation of chondrocyte differentiation
endothelial cell migration
negative regulation of transcription, DNA-templated
response to copper ion
oxidation-reduction process
negative regulation of transcription from RNA polymerase II promoter
endocytosis
positive regulation of epithelial to mesenchymal transition
peptidyl-lysine oxidation
heterochromatin organization
negative regulation of stem cell population maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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