Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: GEGTLESEPA VQVTEVTATS GLVSWGPGRP ADPVWMFQIQ YNSSEDETLI YRIVPASSHH FLLKHLVPGA DYDLC
LRFN4 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: fibronectin type III, immunoglobulin and leucine rich repeat domains 6; Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Gene Aliases: FIGLER6; LRFN4; SALM3; SALM3.
UniProt ID: (Human) Q6PJG9
Entrez Gene ID: (Human) 78999
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support