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Proteintech
LRP2 Polyclonal Antibody
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Product Details
19700-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Amount
48 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to LRP2 and detects endogenous LRP2 with an apparent molecular weight 280 kDa, which is smaller than the predicted molecular weight (522 kDa) and probably represent a proteolytic fragment of the large glycoprotein.
Target Information
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium sensor protein; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; Low-density lipoprotein receptor-related protein 2; LRP-2; Megalin; transmembrane receptor; unnamed protein product
Gene Aliases: DBS; GP330; LRP-2; LRP2
UniProt ID: (Human) P98164
Entrez Gene ID: (Human) 4036
retinoid metabolic process
kidney development
neural tube closure
secondary heart field specification
outflow tract septum morphogenesis
outflow tract morphogenesis
ventricular compact myocardium morphogenesis
ventricular septum development
lipid metabolic process
endocytosis
receptor-mediated endocytosis
nervous system development
heart development
sensory perception of sound
cell proliferation
male gonad development
gene expression
protein transport
cobalamin transport
metal ion transport
negative regulation of BMP signaling pathway
forebrain development
diol metabolic process
aorta development
vitamin D metabolic process
negative regulation of apoptotic process
protein kinase B signaling
response to leptin
transcytosis
positive regulation of neurogenesis
vitamin transport
vagina development
coronary vasculature development
coronary artery morphogenesis
pulmonary artery morphogenesis
positive regulation of oligodendrocyte progenitor proliferation
cellular response to growth factor stimulus
beta-amyloid clearance
neuron projection arborization
transport across blood-brain barrier
folic acid import into cell
cranial skeletal system development
positive regulation of lysosomal protein catabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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