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Proteintech
LRP5 Polyclonal Antibody
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Product Details
24899-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LRP5 Fusion Protein Ag19034 (1332-1397 aa encoded by BC150595)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CDAICLPNQ FRCASGQCVL IKQQCDSFPD CIDGSDELMC EITKPPSDDS PAHSSAIGPV IGIILSL (1332-1397 aa encoded by BC150595)
Target Information
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7; LRP5
Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7; LRP5; LRP7; mKIAA4142; OPPG; OPS; OPTA1; PCLD4; VBCH2
UniProt ID: (Human) O75197, (Mouse) Q91VN0
Entrez Gene ID: (Human) 4041, (Mouse) 16973
gastrulation with mouth forming second
vasculature development
positive regulation of mesenchymal cell proliferation
osteoblast development
glucose catabolic process
amino acid transport
endocytosis
nervous system development
mesodermal cell migration
cholesterol metabolic process
regulation of blood pressure
positive regulation of cell proliferation
organ morphogenesis
tissue development
anterior/posterior pattern specification
gene expression
Wnt signaling pathway
osteoblast proliferation
positive regulation of osteoblast proliferation
somatic stem cell population maintenance
limb morphogenesis
extracellular matrix-cell signaling
cell migration involved in gastrulation
cholesterol homeostasis
embryonic digit morphogenesis
regulation of apoptotic process
response to peptide hormone
small molecule metabolic process
positive regulation of cell differentiation
positive regulation of fat cell differentiation
regulation of osteoblast differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoblast differentiation
positive regulation of cell cycle
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
bone remodeling
blood vessel morphogenesis
bone marrow development
anatomical structure regression
retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
bone development
bone morphogenesis
branching involved in mammary gland duct morphogenesis
mammary gland duct morphogenesis
adipose tissue development
cell-cell signaling involved in mammary gland development
establishment of blood-brain barrier
regulation of insulin secretion involved in cellular response to glucose stimulus
retina vasculature development in camera-type eye
retina vasculature morphogenesis in camera-type eye
retinal blood vessel morphogenesis
regulation of biological quality
cell-cell adhesion
Norrin signaling pathway
apoptotic process involved in patterning of blood vessels
establishment of blood-retinal barrier
multicellular organism development
Wnt signaling pathway involved in dorsal/ventral axis specification
regulation of bone remodeling
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of canonical Wnt signaling pathway
negative regulation of protein serine/threonine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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