Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide derived from human LRP5, amino acids 501-600. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS with 50% glycerol, 1% BSA |
Contains |
0.09% sodium azide |
Storage conditions |
-20°C |
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7
Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP5; LRP7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2
UniProt ID: (Human) O75197, (Mouse) Q91VN0
Entrez Gene ID: (Human) 4041, (Rat) 293649, (Mouse) 16973
Molecular Function:
transmembrane signal receptor
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