Bioss

LRP5 Polyclonal Antibody

View all (11) LRP5 antibodies

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LRP5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded mouse colon carcinoma labeled with Rabbit Anti LRP5 Polyclonal Antibody, Unconjugated (bs-4117R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Product Details

Applications

Tested Dilution

Publications

Immunofluorescence (IF)

Assay-dependent

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Western Blot (WB)

Assay-dependent

-

Product Specifications

Species

Human, Mouse, Rat

Expression System

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human LRP5.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 1% BSA

Contains

0.09% sodium azide

Storage conditions

-20°C

Target Information

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7

Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP5; LRP7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2

UniProt ID: (Human) O75197, (Mouse) Q91VN0

Entrez Gene ID: (Human) 4041, (Rat) 293649, (Mouse) 16973

Molecular Function: extracellular matrix glycoprotein extracellular matrix protein receptor

gastrulation with mouth forming second positive regulation of mesenchymal cell proliferation osteoblast development glucose catabolic process endocytosis cholesterol metabolic process regulation of blood pressure positive regulation of cell proliferation anterior/posterior pattern specification Wnt signaling pathway positive regulation of osteoblast proliferation somatic stem cell population maintenance extracellular matrix-cell signaling cell migration involved in gastrulation cholesterol homeostasis embryonic digit morphogenesis regulation of apoptotic process Wnt signaling pathway involved in dorsal/ventral axis specification positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling regulation of bone remodeling bone marrow development positive regulation of sequence-specific DNA binding transcription factor activity anatomical structure regression retina morphogenesis in camera-type eye canonical Wnt signaling pathway bone morphogenesis branching involved in mammary gland duct morphogenesis adipose tissue development cell-cell signaling involved in mammary gland development regulation of canonical Wnt signaling pathway regulation of insulin secretion involved in cellular response to glucose stimulus retinal blood vessel morphogenesis negative regulation of protein serine/threonine kinase activity apoptotic process involved in patterning of blood vessels beta-catenin destruction complex disassembly vasculature development regulation of ossification embryonic limb morphogenesis limb morphogenesis response to peptide hormone regulation of fat cell differentiation embryonic camera-type eye morphogenesis embryonic retina morphogenesis in camera-type eye bone development mammary gland duct morphogenesis retina vasculature morphogenesis in camera-type eye multicellular organism development

Process(es)

protein binding Wnt-protein binding toxin transporter activity Wnt-activated receptor activity coreceptor activity involved in Wnt signaling pathway coreceptor activity involved in canonical Wnt signaling pathway molecular_function coreceptor activity