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LRP5 Polyclonal Antibody

View all (14) LRP5 antibodies

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LRP5 Polyclonal Antibody

Product Details

BS-4117R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human LRP5, amino acids 501-600.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7; LRP5

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Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7; LRP5; LRP7; mKIAA4142; OPPG; OPS; OPTA1; PCLD4; VBCH2

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UniProt ID: (Human) O75197, (Mouse) Q91VN0

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Entrez Gene ID: (Human) 4041, (Rat) 293649, (Mouse) 16973

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Function(s)
protein binding coreceptor activity Wnt-protein binding toxin transporter activity Wnt-activated receptor activity molecular_function transmembrane signal receptor
Process(es)
gastrulation with mouth forming second vasculature development positive regulation of mesenchymal cell proliferation osteoblast development glucose catabolic process amino acid transport endocytosis nervous system development mesodermal cell migration cholesterol metabolic process regulation of blood pressure positive regulation of cell proliferation organ morphogenesis tissue development anterior/posterior pattern specification gene expression Wnt signaling pathway osteoblast proliferation positive regulation of osteoblast proliferation somatic stem cell population maintenance limb morphogenesis extracellular matrix-cell signaling cell migration involved in gastrulation cholesterol homeostasis embryonic digit morphogenesis regulation of apoptotic process response to peptide hormone small molecule metabolic process positive regulation of cell differentiation positive regulation of fat cell differentiation regulation of osteoblast differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling blood vessel morphogenesis bone marrow development anatomical structure regression retina morphogenesis in camera-type eye canonical Wnt signaling pathway bone development bone morphogenesis branching involved in mammary gland duct morphogenesis mammary gland duct morphogenesis adipose tissue development cell-cell signaling involved in mammary gland development establishment of blood-brain barrier regulation of insulin secretion involved in cellular response to glucose stimulus retina vasculature development in camera-type eye retina vasculature morphogenesis in camera-type eye retinal blood vessel morphogenesis regulation of biological quality cell-cell adhesion Norrin signaling pathway apoptotic process involved in patterning of blood vessels establishment of blood-retinal barrier regulation of ossification embryonic limb morphogenesis Wnt signaling pathway involved in dorsal/ventral axis specification regulation of fat cell differentiation regulation of bone remodeling embryonic camera-type eye morphogenesis positive regulation of sequence-specific DNA binding transcription factor activity embryonic retina morphogenesis in camera-type eye regulation of canonical Wnt signaling pathway negative regulation of protein serine/threonine kinase activity multicellular organism development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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