Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Positive Samples: Mouse liver, Rat liver; Cellular Location: Endoplasmic reticulum, Membrane, Single-pass type I membrane protein
Immunogen sequence: YAGANGPFPH EYVSGTPHVP L
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HGNC:6697; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7
Gene Aliases: BMND1; HBM; LR3; Lrp5; LRP7; mKIAA4142; OPPG
UniProt ID: (Mouse) Q91VN0
Entrez Gene ID: (Rat) 293649, (Mouse) 16973
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support