Applications | Tested Dilution | Publications |
---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200 | - |
ELISA (ELISA) |
1:500-1:1,000 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide derived from human LRP6. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS with 1% BSA, 50% glycerol |
Contains |
0.09% sodium azide |
Storage conditions |
-20°C |
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: crooked; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein receptor-related protein 7; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-6; LRP-7
Gene Aliases:
ADCAD2; BMND1; C030016K15Rik; Cd; EVR1; EVR4; Gw; HBM; LR3; LRP-5; LRP5; LRP6; LRP7; mKIAA4142; OPPG; OPS; OPTA1; ska26; ska
UniProt ID: (Human) O75197, (Human) O75581, (Mouse) Q91VN0, (Mouse) O88572
Entrez Gene ID: (Human) 4041, (Human) 4040, (Rat) 293649, (Mouse) 16973, (Rat) 312781, (Mouse) 16974
Molecular Function:
apolipoprotein
transmembrane signal receptor
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