Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: crooked; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6
Gene Aliases:
ADCAD2; C030016K15Rik; Cd; Gw; LRP6; ska26; ska
UniProt ID: (Human) O75581, (Mouse) O88572
Entrez Gene ID: (Human) 4040, (Rat) 312781, (Mouse) 16974
Molecular Function:
apolipoprotein
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