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LRP6 Antibody (PA5-13145) in IHC (P)
Immunohistochemistry analysis of LRP6 in formalin-fixed and paraffin-embedded human breast carcinoma tissue. Samples were incubated with LRP6 polyclonal antibody (Product # PA5-13145) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-13145
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2139317
Target Information
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6
Gene Aliases: ADCAD2; LRP6; STHAG7
UniProt ID: (Human) O75581
Entrez Gene ID: (Human) 4040
low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
apolipoprotein binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway
apolipoprotein
neural tube closure
negative regulation of protein phosphorylation
pericardium morphogenesis
negative regulation of protein kinase activity
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
embryonic pattern specification
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
single organismal cell-cell adhesion
cerebellum morphogenesis
thalamus development
cerebral cortex development
midbrain-hindbrain boundary development
negative regulation of smooth muscle cell apoptotic process
external genitalia morphogenesis
odontogenesis of dentin-containing tooth
response to peptide hormone
Wnt signaling pathway involved in dorsal/ventral axis specification
canonical Wnt signaling pathway involved in neural crest cell differentiation
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
convergent extension
embryonic retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
face morphogenesis
trachea cartilage morphogenesis
cellular response to cholesterol
dopaminergic neuron differentiation
negative regulation of protein serine/threonine kinase activity
protein localization to plasma membrane
primitive streak formation
negative regulation of canonical Wnt signaling pathway
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Wnt signaling pathway involved in somitogenesis
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
toxin transport
beta-catenin destruction complex disassembly
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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