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Invitrogen
LRP6 Polyclonal Antibody
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FIGURE: 1 / 2
LRP6 Antibody (PA5-13145) in IHC (P)
Immunohistochemistry analysis of LRP6 in formalin-fixed and paraffin-embedded human breast carcinoma tissue. Samples were incubated with LRP6 polyclonal antibody (Product # PA5-13145) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-13145
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Amount
480 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ90062; FLJ90421; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6; transmembrane protein; unnamed protein product
Gene Aliases: ADCAD2; LRP6; STHAG7
UniProt ID: (Human) O75581
Entrez Gene ID: (Human) 4040
low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
coreceptor activity
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
protein serine/threonine kinase inhibitor activity
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
regulation of transcription, DNA-templated
endocytosis
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
nervous system development
tissue development
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
vesicle-mediated transport
midbrain development
negative regulation of smooth muscle cell apoptotic process
regulation of apoptotic process
chordate embryonic development
response to peptide hormone
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
transmembrane transport
canonical Wnt signaling pathway
cellular response to cholesterol
dopaminergic neuron differentiation
protein localization to plasma membrane
cell-cell adhesion
midbrain dopaminergic neuron differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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