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LRP6 Polyclonal Antibody
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FIGURE: 1 / 3
LRP6 Antibody (PA5-18317) in IHC (P)
Immunohistochemistry analysis of LRP6 in human hepatocytes and bile duct. Samples were incubated with LRP6 polyclonal antibody (Product # PA5-18317) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18317
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (CMTSVATAKGYTSDL) corresponding to the internal amino acids of LRP6 (aa 1551-1561).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ90062; FLJ90421; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6; transmembrane protein; unnamed protein product
Gene Aliases: ADCAD2; LRP6; STHAG7
UniProt ID: (Human) O75581
Entrez Gene ID: (Human) 4040
low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
coreceptor activity
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
protein serine/threonine kinase inhibitor activity
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
regulation of transcription, DNA-templated
endocytosis
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
nervous system development
tissue development
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
vesicle-mediated transport
midbrain development
negative regulation of smooth muscle cell apoptotic process
regulation of apoptotic process
chordate embryonic development
response to peptide hormone
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
transmembrane transport
canonical Wnt signaling pathway
cellular response to cholesterol
dopaminergic neuron differentiation
protein localization to plasma membrane
cell-cell adhesion
midbrain dopaminergic neuron differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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