In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse LRP-6 is observed, and less than 1% cross-reactivity with recombinant human (rh) LRP-1, rhLRP-4, and rhLRP-5 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes a member of the low density lipoprotein receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- processing but the precise locations of the cleavage sites have not been determined.
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Protein Aliases: ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6; LRP6
Gene Aliases: ADCAD2; LRP6; STHAG7
UniProt ID: (Human) O75581
Entrez Gene ID: (Human) 4040