Invitrogen

LRP6 Polyclonal Antibody

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This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details

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LRP6 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of LRP6 in human kidney and lymph node tissues using a LRP6 polyclonal antibody (Product # PA5-83114). Corresponding RNA-seq data are presented for the same tissues.

LRP6 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of LRP6 in human lymph node using a LRP6 polyclonal antibody (Product # PA5-83114). The analysis shows low expression as expected.

LRP6 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of LRP6 in human kidney using a LRP6 polyclonal antibody (Product # PA5-83114). The analysis shows high expression.

LRP6 Antibody in Relative expression — Relative expression in different tissues in IHC: Detection of differential expression levels of LRP6 demonstrates antibody specificity. Immunohistochemical analysis of LRP6 using anti-LRP6 Polyclonal Antibody (Product #PA5-83114), shows significant staining of LRP6 in kidney and shows minimal or weak staining in lymph node tissues. The relative expression levels of LRP6 within each tissue is shown using RNA-Seq. {RE}

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LRP6

Conjugate

Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2790270

Product Specific Information

Immunogen sequence: GALRCNGDAN CQDKSDEKNC EVLCLIDQFR CANGQCIGKH KKCDHNVDCS DKSDELDCYP TEEPAPQ

Target Information

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6

Gene Aliases: ADCAD2; LRP6; STHAG7

UniProt ID: (Human) O75581

Entrez Gene ID: (Human) 4040

Molecular Function: extracellular matrix glycoprotein extracellular matrix protein receptor

neural tube closure negative regulation of protein phosphorylation pericardium morphogenesis negative regulation of protein kinase activity positive regulation of cytosolic calcium ion concentration chemical synaptic transmission embryonic pattern specification neural crest formation neural crest cell differentiation Wnt signaling pathway single organismal cell-cell adhesion cerebellum morphogenesis thalamus development cerebral cortex development midbrain-hindbrain boundary development negative regulation of smooth muscle cell apoptotic process external genitalia morphogenesis odontogenesis of dentin-containing tooth response to peptide hormone Wnt signaling pathway involved in dorsal/ventral axis specification canonical Wnt signaling pathway involved in neural crest cell differentiation canonical Wnt signaling pathway involved in regulation of cell proliferation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity palate development convergent extension embryonic retina morphogenesis in camera-type eye canonical Wnt signaling pathway face morphogenesis trachea cartilage morphogenesis cellular response to cholesterol dopaminergic neuron differentiation negative regulation of protein serine/threonine kinase activity protein localization to plasma membrane primitive streak formation negative regulation of canonical Wnt signaling pathway receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Wnt signaling pathway involved in somitogenesis axis elongation involved in somitogenesis positive regulation of canonical Wnt signaling pathway toxin transport beta-catenin destruction complex disassembly midbrain dopaminergic neuron differentiation Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

Process(es)

low-density lipoprotein receptor activity receptor binding frizzled binding protein binding Wnt-protein binding kinase inhibitor activity toxin transporter activity apolipoprotein binding identical protein binding protein homodimerization activity Wnt-activated receptor activity coreceptor activity involved in Wnt signaling pathway coreceptor activity involved in canonical Wnt signaling pathway