Immunogen sequence: RSDSKSSPQA GRRYGVQVMG SGLLAEMKAK QEKRAACAQK KLGNDAVSQD SSSPALSSVE RSDGGGAVPK LHPGLPENRF GLGTPEKNTK AEPKAEA
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 77%.
Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization. May control actin dynamics in lamellipodia. Required for cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Capping protein regulator and myosin 1 linker protein 1; Capping protein, Arp2/3 and myosin-I linker homolog 1; Capping protein, Arp2/3 and myosin-I linker protein 1; capping protein, Arp2/3, and Myosin-I Linker homolog 1; CARMIL; CARMIL homolog; CARMIL1a; F-actin-uncapping protein LRRC16A; leucine rich repeat containing 16; leucine rich repeat containing 16A; Leucine-rich repeat-containing protein 16A; LRRC16; LRRC16A; testicular tissue protein Li 107
Gene Aliases: CARMIL; CARMIL1; CARMIL1a; dJ501N12.1; dJ501N12.5; LRRC16; LRRC16A
UniProt ID: (Human) Q5VZK9
Entrez Gene ID: (Human) 55604