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Invitrogen
LRRC4 Polyclonal Antibody
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FIGURE: 1 / 1
LRRC4 Antibody (PA5-78649) in WB
Western Blot using LRRC4 Polyclonal Antibody (Product # PA5-78649). Various tissue extracts (75 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with LRRC4 Polyclonal Antibody (Product # PA5-78649) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-78649
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Intracellular domain of mouse LRRC4. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: m brain, brain
Predicted Reactivity: Human (98%), Rhesus Monkey (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain tumor-associated protein MBAG1; leucine rich repeat containing 4 protein; Leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4-like protein; Netrin-G2 ligand; NGL-2; NLG2; protein NGL-2
Gene Aliases: Lrrc4; MBAG1; Nag14; NGL-2; NLG-2
UniProt ID: (Mouse) Q99PH1, (Rat) Q45R42
Entrez Gene ID: (Mouse) 192198, (Rat) 641521
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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