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Proteintech
LRRFIP1 Polyclonal Antibody
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Product Details
31186-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LRRFIP1 fusion protein Ag34760
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EEEGEETGLR DEKPIKTEVP GSPAGTEGNC QEATGPSTVD TQNEPLDMKE PDEEKSDQQG EAFDSSQKKT KNKKKKNKKK KSPVPVETLK DVKKELTYQN TDLSEIKEEE QVKSTDRKSA VEAQNEVTEN PKQKIAAESS ENVDCPENPK IKLDGKLDQE GDDVQTAAEE VLADGDTLDF EDDTVQSSGP RAGGEELDEG VAKDNAKIDG ATQSSPAEPK SEDADRCTLP EHESPSQDIS DACEAESTER CEMSEHPSQT VRKALDSNSL ENDDLSAPGR EPGHFNPESR EDTRGGNEKG KSKEDCTMS
Target Information
Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein which mediates either induction or repression of TLR signaling. Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity. Flap-1 or LRRFIP1 was also shown to bind the TNF- -308 promoter polymorphism site, suggesting its possible role in the regulation of TNF- production. FLAP-1 along with LRRFIP2 and FLIIH serve as a balance in coordinating inflammatory response after infection, and may act as a novel target in the control of agonist-induced TLR-mediated inflammatory and autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GC-binding factor 2; HUFI1; leucine rich repeat (in FLII) interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; NEDD8-conjugating enzyme; TAR RNA-interacting protein
Gene Aliases: FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; LRRFIP1; TRIP
UniProt ID: (Human) Q32MZ4
Entrez Gene ID: (Human) 9208
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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