|Tested species reactivity||Horse, Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (FDQRNYSSLRHSKPTSA (aa151-167)) of LRRFIP2 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) belongs to the LRRFIP family. LRRFIP2 has multifaceted functions in innate immunity, apoptosis and development. LRRFIP2 can bind to MyD88 and positively regulate TLR activity as measured by NF-kB activity and cytokine production in macrophages. LPS stimulation also increases LRRFIP2 expression in macrophages. By interacting with Dvl, LRRFIP2 increases the cellular levels of ß-catenin and activate ß-catenin/LEF/TCF-dependent transcriptional activity. A dominant negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation. LRRFIP2 also interacts with Caspase-11 through Flightless-I protein and may be involved in the regulation of proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.