Suggested positive control: mouse brain lysate, mouse brain protein.
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
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Protein Aliases: Leucine-rich repeat serine/threonine-protein kinase 2; LRRK 2; LRRK-2; PARK8; ROCO2
Gene Aliases: 4921513O20Rik; 9330188B09Rik; AW561911; cI-46; D630001M17Rik; Gm927; Lrrk2
UniProt ID: (Mouse) Q5S006
Entrez Gene ID: (Mouse) 66725