The target sequence has 88% sequence homology with mouse and rat.
Suggested positive control: human brain lysate.
The novel LRRK2 gene (also known as PARK8), is responsible for up to 6% of all autosomal dominant Parkinson's disease (PD). LRRK2 missense mutations segregate with PARK8-linked PD and are implicated in other neurodegenerative diseases involving alpha-synuclein and tau pathology.
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Protein Aliases: augmented in rheumatoid arthritis 17; AURA17; DARDARIN; leucine-rich repeat kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; PARK8; RIPK7; ROCO2
Gene Aliases: AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2
UniProt ID: (Human) Q5S007
Entrez Gene ID: (Human) 120892