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Proteintech
LRRTM1 Polyclonal Antibody
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Product Details
14288-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LRRTM1 Fusion Protein Ag5602 (30-351 aa encoded by BC045113)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QMLPAAPSG CPQLCRCEGR LLYCEALNLT EAPHNLSGLL GLSLRYNSLS ELRAGQFTGL MQLTWLYLDH NHICSVQGDA FQKLRRVKEL TLSSNQITQL PNTTFRPMPN LRSVDLSYNK LQALAPDLFH GLRKLTTLHM RANAIQFVPV RIFQDCRSLK FLDIGYNQLK SLARNSFAGL FKLTELHLEH NDLVKVNFAH FPRLISLHSL CLRRNKVAIV VSSLDWVWNL EKMDLSGNEI EYMEPHVFET VPHLQSLQLD SNRLTYIEPR ILNSWKSLTS ITLAGNLWDC GRNVCALASW LSNFQGRYDG NLQCASPEYA QGE (30-351 aa encoded by BC045113)
Target Information
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM1 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leucine-rich repeat transmembrane neuronal 1; leucine-rich repeat transmembrane neuronal 1 protein; Leucine-rich repeat transmembrane neuronal protein 1
Gene Aliases: 4632401D06Rik; AW125451; LRRTM1; UNQ675/PRO1309
UniProt ID: (Rat) D4A6D8, (Human) D6W5K1, (Mouse) Q8K377
Entrez Gene ID: (Rat) 679668, (Human) 347730, (Mouse) 74342
negative regulation of receptor internalization
locomotory behavior
protein localization to synapse
exploration behavior
synapse organization
long-term synaptic potentiation
negative regulation of protein kinase activity
biological_process
cytokine-mediated signaling pathway
negative regulation of JAK-STAT cascade
positive regulation of synapse assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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