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A suggested positive control is mouse brain tissue lysate.
PA5-21098 can be used with blocking peptide PEP-1212.
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the A-beta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma A-beta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.
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Protein Aliases: Leucine-rich repeat transmembrane neuronal protein 3
Gene Aliases: 9630044H04Rik; LRRTM3; UNQ803/PRO1693
Molecular Function: transmembrane signal receptor