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This target displays homology in the following species: Cow: 85%; Dog: 92%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Mouse: 85%; Pig: 92%; Rabbit: 92%; Rat: 85%; Yeast: 100%
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CENP-33; Centromere protein 33; Leucine-rich repeat and WD repeat-containing protein 1; leucine-rich repeats and WD repeat domain containing 1; ORC-associated protein; ORCA; Origin recognition complex-associated protein; testicular tissue protein Li 4
Gene Aliases: 1200011O22Rik; AU042569; AW548074; BOS_23126; CENP-33; LRWD1; ORCA
UniProt ID: (Human) Q9UFC0, (Mouse) Q8BUI3
Entrez Gene ID: (Rat) 304396, (Bovine) 100138861, (Dog) 479725, (Rabbit) 100337872, (Human) 222229, (Guinea pig) 100735189, (Mouse) 71735
Molecular Function:
extracellular matrix protein
receptor
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