Search
Invitrogen
LRWD1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-90566
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Lrwd1 (NP_6908521)
Conjugate
Form
Liquid
Concentration
1.85 mg/mL
Amount
185 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QELDLSNNHL ETLPDNLGLS HLRVLRCANN QLGDVTALCQ FPKLEELSLE GNPFLTVNDN LKVSFLLPTL RKVNGKDASS TYSQVENLNR ELTSRVTAHW E
Positive Samples: U-87MG, HeLa, HepG2, Jurkat, Mouse testis, Mouse thymus, Rat testis; Cellular Location: Chromosome, Cytoplasm, Nucleus, centromere, centrosome, cytoskeleton, microtubule organizing center, telomere
Target Information
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CENP-33; Centromere protein 33; Leucine-rich repeat and WD repeat-containing protein 1; ORC-associated protein; ORCA; Origin recognition complex-associated protein; testicular tissue protein Li 4; unnamed protein product
Gene Aliases: 1200011O22Rik; AU042569; AW548074; CENP-33; LRWD1; ORCA
UniProt ID: (Human) Q9UFC0, (Mouse) Q8BUI3
Entrez Gene ID: (Rat) 304396, (Human) 222229, (Mouse) 71735
chromatin organization
transcription, DNA-templated
protein phosphorylation
cell proliferation
cytokine-mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
establishment of protein localization to chromatin
DNA replication
DNA replication initiation
chromatin modification
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support