Keep as concentrated solution.
Positive Control: NT2D1, IMR32, MCF-7, PC-12, Rat2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 110 kDa subunit antibody; amine oxidase (flavin containing) domain 2; amine oxidase (flavin containing) domain 2 antibody; AOF2 antibody; BHC110 antibody; BRAF35-HDAC complex protein BHC110; BRAF35-HDAC complex protein BHC110 antibody; FAD-binding protein BRAF35-HDAC complex; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; flavin-containing amine oxidase domain-containing protein 2 antibody; KDM1 antibody; KDM1A antibody; KIAA0601 antibody; LSD1 antibody; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1 antibody; lysine (K)-specific demethylase 1A; lysine (K)-specific demethylase 1A antibody; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1 antibody; Lysine-specific histone demethylase 1A; lysine-specific histone demethylase 1A antibody; neuroprotective protein 3
Gene Aliases: AOF2; BHC110; CPRF; KDM1; KDM1A; KIAA0601; LSD1; RGD1562975
UniProt ID: (Human) O60341