The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
Protein Aliases: LT beta-R; LT-beta receptor; lymphotoxin B receptor; lymphotoxin beta receptor (TNFR superfamily, member 3); Lymphotoxin-beta receptor; TNF receptor-related protein; TNF-RIII; TNFR-III; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3; Tumor necrosis factor receptor type III
Gene Aliases: AI256028; CD18; D12S370; LT-BETA-R; Ltar; LTbetaR; LTBR; TNF-R-III; Tnfbr; TNFCR; TNFR-RP; TNFR2-RP; TNFR3; TNFRrp; TNFRSF3
Molecular Function: transmembrane signal receptor