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Invitrogen
LTK Polyclonal Antibody
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FIGURE: 1 / 4
LTK Antibody (PA5-106479) in ICC/IF
Immunofluorescent analysis of LTK in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and LTK polyclonal antibody (Product # PA5-106479) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-106479
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LTK(Accession P29376), corresponding to amino acid residues R221-A271.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total LTK.
Target Information
LTK (TYK1), ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the Insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B-lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domain of ALK is expressed as the result of a translocation occurring in many non-Hodgkin's lymphomas. The c-Ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.1.112; EC 2.7.10.1; leukocyte receptor tyrosine kinase; Leukocyte tyrosine kinase receptor; ltk; Protein tyrosine kinase 1; tyrosine kinase-1; unnamed protein product
Gene Aliases: LTK; TYK1
UniProt ID: (Human) P29376, (Mouse) P08923
Entrez Gene ID: (Human) 4058, (Rat) 311337, (Mouse) 17005
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
receptor signaling protein tyrosine kinase activator activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell proliferation
positive regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of apoptotic process
regulation of neuron differentiation
positive regulation of protein kinase B signaling
cellular response to retinoic acid
phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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