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Invitrogen
LTK Polyclonal Antibody
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Product Details
PA5-75282
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 210-260 of Human LTK.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719010
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
LTK (TYK1), ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the Insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B-lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domain of ALK is expressed as the result of a translocation occurring in many non-Hodgkin's lymphomas. The c-Ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.1.112; EC 2.7.10.1; leukocyte receptor tyrosine kinase; Leukocyte tyrosine kinase receptor; Protein tyrosine kinase 1; tyrosine kinase-1
Gene Aliases: LTK; TYK1
UniProt ID: (Human) P29376, (Mouse) P08923
Entrez Gene ID: (Human) 4058, (Rat) 311337, (Mouse) 17005
protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell proliferation
positive regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
negative regulation of apoptotic process
cellular response to retinoic acid
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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