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Active Motif
LXR-alpha Polyclonal Antibody
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Product Details
61175
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This LXR-alpha antibody was raised against a peptide in the N-terminal region of human LXR-alpha.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
Antigen affinity chromatography, Affinity chromatography
Storage buffer
70mM tris, pH 7.5, with 30% glycerol, 105mM EDTA, 31mM glycine
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Liver X receptor alpha; LXR alpha; LXRb; NER; NERI; NR1H2; Nuclear receptor subfamily 1 group H member 3; Oxysterols receptor LXR-alpha; ubiquitously-expressed nuclear receptor 1; unnamed protein product
Gene Aliases: AU018371; LXR; LXR-a; LXRA; NR1H3; RLD-1; RLD1; Unr1
UniProt ID: (Human) Q13133, (Mouse) Q9Z0Y9
Entrez Gene ID: (Human) 10062, (Mouse) 22259
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
cholesterol binding
chromatin DNA binding
sterol response element binding
sequence-specific DNA binding
metal ion binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
steroid hormone receptor activity
transcription regulatory region DNA binding
retinoid X receptor binding
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
lipid metabolic process
hormone-mediated signaling pathway
negative regulation of macrophage derived foam cell differentiation
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol efflux
regulation of lipid storage
negative regulation of cholesterol storage
cell differentiation
intracellular receptor signaling pathway
negative regulation of lipid transport
positive regulation of cholesterol transport
response to progesterone
positive regulation of toll-like receptor 4 signaling pathway
phosphatidylcholine acyl-chain remodeling
cholesterol homeostasis
regulation of circadian rhythm
mRNA transcription from RNA polymerase II promoter
negative regulation of macrophage activation
apoptotic cell clearance
positive regulation of fatty acid biosynthetic process
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of lipid biosynthetic process
negative regulation of pinocytosis
negative regulation of inflammatory response
lipid homeostasis
sterol homeostasis
negative regulation of interferon-gamma-mediated signaling pathway
triglyceride homeostasis
cellular response to lipopolysaccharide
negative regulation of pancreatic juice secretion
negative regulation of secretion of lysosomal enzymes
negative regulation of cold-induced thermogenesis
negative regulation of response to endoplasmic reticulum stress
transcription, DNA-templated
transcription from RNA polymerase II promoter
fatty acid biosynthetic process
positive regulation of receptor biosynthetic process
positive regulation of cellular protein metabolic process
steroid hormone mediated signaling pathway
cellular lipid metabolic process
positive regulation of lipoprotein lipase activity
regulation of cholesterol homeostasis
positive regulation of cholesterol homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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