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LXR-alpha Polyclonal Antibody

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View all (18) LXR alpha antibodies

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LXR-alpha Polyclonal Antibody

Product Details

61175

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ChIP assay (ChIP)

10 µL
View 1 publication 1 publication

ChIP-sequencing (ChIP-Seq)

10 µL
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This LXR-alpha antibody was raised against a peptide in the N-terminal region of human LXR-alpha.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Purification

Antigen affinity chromatography, Affinity chromatography

Storage buffer

70mM tris, pH 7.5, with 30% glycerol, 105mM EDTA, 31mM glycine

Contains

0.035% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2614981

Target Information

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Liver X receptor alpha; LXR alpha; LXRb; NER; NERI; NR1H2; Nuclear receptor subfamily 1 group H member 3; Oxysterols receptor LXR-alpha; ubiquitously-expressed nuclear receptor 1; unnamed protein product

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Gene Aliases: AU018371; LXR; LXR-a; LXRA; NR1H3; RLD-1; RLD1; Unr1

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UniProt ID: (Human) Q13133, (Mouse) Q9Z0Y9

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Entrez Gene ID: (Human) 10062, (Mouse) 22259

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding cholesterol binding chromatin DNA binding sterol response element binding sequence-specific DNA binding metal ion binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding steroid hormone receptor activity transcription regulatory region DNA binding retinoid X receptor binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated lipid metabolic process hormone-mediated signaling pathway negative regulation of macrophage derived foam cell differentiation positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux regulation of lipid storage negative regulation of cholesterol storage cell differentiation intracellular receptor signaling pathway negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone positive regulation of toll-like receptor 4 signaling pathway phosphatidylcholine acyl-chain remodeling cholesterol homeostasis regulation of circadian rhythm mRNA transcription from RNA polymerase II promoter negative regulation of macrophage activation apoptotic cell clearance positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of lipid biosynthetic process negative regulation of pinocytosis negative regulation of inflammatory response lipid homeostasis sterol homeostasis negative regulation of interferon-gamma-mediated signaling pathway triglyceride homeostasis cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes negative regulation of cold-induced thermogenesis negative regulation of response to endoplasmic reticulum stress transcription, DNA-templated transcription from RNA polymerase II promoter fatty acid biosynthetic process positive regulation of receptor biosynthetic process positive regulation of cellular protein metabolic process steroid hormone mediated signaling pathway cellular lipid metabolic process positive regulation of lipoprotein lipase activity regulation of cholesterol homeostasis positive regulation of cholesterol homeostasis
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